Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.71 |
| ▸ | DPP8 | Q6V1X1 | 9/20 | 0.71 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.65 |
| ▸ | ACE | P12821 | 1/20 | 0.65 |
| ▸ | HTR2A | P28223 | 1/20 | 0.65 |
| ▸ | FAP | Q12884 | 1/20 | 0.65 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8223790 | 0.89 | DPP4 (0.74) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL8223711 | 0.87 | DPP4 (0.73) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL8224713 | 0.87 | DPP4 (0.74) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL8205523 | 0.84 | DPP4 (0.66) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL15042309 | 0.83 | DPP4 (0.85) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL8225334 | 0.83 | DPP4 (0.50) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL8226443 | 0.83 | DPP4 (0.64) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL1934835 | 0.79 | DPP4 (0.81) | DPP4DPP8DPP9ACEHTR2A | |
| Sitagliptin SCHEMBL1289311 | 0.79 | DPP4 (1.00) | DPP4DPP8DPP9ACEHTR2A | |
| Sitagliptin SCHEMBL174489 | 0.79 | DPP4 (1.00) | DPP4DPP8DPP9ACEHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040974-A1 | INDOLES FOR USE AS DPP-IV INHIBITORS | PEAKDALE MOLECULAR LIMITED (GB) | 2008-04-10 | — | — | WO | disclosed |