Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 18/20 | 0.50 |
| ▸ | DPP8 | Q6V1X1 | 8/20 | 0.50 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | FAP | Q12884 | 1/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8223780 | 0.88 | DPP4 (0.53) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL8227443 | 0.83 | DPP4 (0.71) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL16993649 | 0.82 | DPP4 (0.56) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL8223485 | 0.82 | DPP4 (0.47) | DPP4DPP8DPP9DPP7PARP1 | |
| SCHEMBL25304263 | 0.75 | DPP4 (0.69) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL8223790 | 0.72 | DPP4 (0.74) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL22897326 | 0.71 | DPP4 (0.55) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL8205523 | 0.70 | DPP4 (0.66) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL8223711 | 0.70 | DPP4 (0.73) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL8217514 | 0.70 | DPP4 (0.55) | DPP4DPP8DPP9ACEHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040974-A1 | INDOLES FOR USE AS DPP-IV INHIBITORS | PEAKDALE MOLECULAR LIMITED (GB) | 2008-04-10 | — | — | WO | disclosed |