Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 5/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | CDK14 | O94921 | 2/20 | 0.36 |
| ▸ | CCNY | Q8ND76 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | GRK2 | P25098 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8219257 | 0.87 | CDK2 (0.56) | CDK2CCNA2ADORA2AADORA1CHRM1 | |
| SCHEMBL8219161 | 0.87 | CCNA2 (0.63) | CDK2CCNA2ADORA2AADORA1CHRM1 | |
| SCHEMBL8261337 | 0.84 | CCNA2 (0.57) | CDK2CCNA2ADORA2AADORA1CHRM1 | |
| SCHEMBL8226199 | 0.83 | CCNA2 (0.53) | CDK2CCNA2ADORA2ACHRM3PIM1 | |
| SCHEMBL8228035 | 0.82 | CCNA2 (0.55) | CDK2CCNA2ADORA2AADORA1GSK3B | |
| SCHEMBL8219744 | 0.82 | CDK2 (0.50) | CDK2CCNA2ADORA2AADORA1CHRM1 | |
| SCHEMBL8262274 | 0.82 | CDK2 (0.50) | CDK2CCNA2ADORA2AADORA1CHRM1 | |
| SCHEMBL13543788 | 0.80 | CCNA2 (0.48) | CDK2CCNA2ADORA2AADORA1CHRM3 | |
| SCHEMBL1286718 | 0.80 | CDK2 (0.50) | CDK2CCNA2ADORA2AADORA1CHRM1 | |
| SCHEMBL16995287 | 0.79 | CDK2 (0.45) | CDK2CCNA2ADORA2AADORA1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009954-A1 | MEDICAL USE OF CYCLIN DEPENDENT KINASES INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |