Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 5/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8228763 | 0.94 | ELANE (0.47) | KDM4EALDH1A1SMN1; SMN2ELANENOTUM | |
| SCHEMBL8053624 | 0.88 | ELANE (0.49) | KDM4EALDH1A1SMN1; SMN2ELANENOTUM | |
| SCHEMBL8234302 | 0.88 | ALDH1A1 (0.48) | KDM4EALDH1A1SMN1; SMN2ELANENOTUM | |
| SCHEMBL8065188 | 0.85 | ELANE (0.63) | KDM4EALDH1A1SMN1; SMN2ELANENOTUM | |
| SCHEMBL8065817 | 0.84 | ELANE (0.42) | KDM4EALDH1A1SMN1; SMN2ELANENOTUM | |
| SCHEMBL1604233 | 0.79 | KDM4E (0.49) | KDM4EALDH1A1SMN1; SMN2ELANENOTUM | |
| SCHEMBL8237728 | 0.79 | ELANE (0.41) | KDM4EALDH1A1SMN1; SMN2ELANENOTUM | |
| SCHEMBL4024439 | 0.79 | ELANE (0.76) | ELANE | |
| SCHEMBL8220630 | 0.76 | ELANE (0.38) | KDM4EALDH1A1SMN1; SMN2ELANENOTUM | |
| SCHEMBL8234449 | 0.76 | ELANE (0.54) | KDM4EALDH1A1SMN1; SMN2ELANENOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007107706-A2 | DIMERS OF HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF COPD | ARGENTA DISCOVERY LIMITED (GB) | 2007-09-27 | — | — | WO | disclosed |