Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.63 |
| ▸ | DRD3 | P35462 | 12/20 | 0.63 |
| ▸ | DRD4 | P21917 | 7/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.59 |
| ▸ | HTR1A | P08908 | 3/20 | 0.59 |
| ▸ | DRD1 | P21728 | 2/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | HTR2C | P28335 | 2/20 | 0.57 |
| ▸ | HTR2B | P41595 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3977318 | 0.92 | DRD2 (0.66) | DRD2DRD3DRD4ADRA1AADRA1D | |
| SCHEMBL8233390 | 0.91 | DRD2 (0.65) | DRD2DRD3DRD4ADRA1AADRA1D | |
| SCHEMBL3975981 | 0.90 | DRD2 (0.66) | DRD2DRD3DRD4ADRA1AADRA1D | |
| SCHEMBL13484855 | 0.89 | DRD3 (0.55) | DRD2DRD3DRD4ADRA1AADRA1D | |
| Hydrochloric Acid SCHEMBL3972636 | 0.89 | DRD2 (0.65) | DRD2DRD3DRD4ADRA1AADRA1D | |
| SCHEMBL8229501 | 0.88 | DRD2 (0.55) | DRD2DRD3DRD4ADRA1AADRA1D | |
| SCHEMBL3980714 | 0.87 | DRD2 (0.51) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL13484922 | 0.86 | DRD3 (0.57) | DRD2DRD3DRD4ADRA1AADRA1D | |
| SCHEMBL3981789 | 0.86 | DRD2 (0.65) | DRD2DRD3DRD4ADRA1AADRA1D | |
| SCHEMBL3982187 | 0.86 | DRD2 (0.46) | DRD2DRD3DRD4ADRA1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009741-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | PIERRE FABRE MEDICAMENT (FR) | 2008-01-24 | — | — | WO | disclosed |