Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.41 |
| ▸ | SCD5 | Q86SK9 | 5/20 | 0.38 |
| ▸ | SCD | O00767 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | CPT1A | P50416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8226950 | 0.97 | HCRTR1 (0.44) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL2889901 | 0.88 | SMN1; SMN2 (0.48) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL2899332 | 0.88 | SMN1; SMN2 (0.48) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL2896726 | 0.86 | HCRTR1 (0.51) | HCRTR1HCRTR2SCD5SCDGRM5 | |
| SCHEMBL13412244 | 0.86 | HCRTR1 (0.51) | HCRTR1HCRTR2SCD5SCDGRM5 | |
| SCHEMBL5630003 | 0.85 | SCD5 (0.53) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL4076414 | 0.85 | SCD5 (0.53) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL3974945 | 0.85 | HCRTR1 (0.54) | NPC1RAB9AHCRTR1HCRTR2SCD5 | |
| SCHEMBL13412243 | 0.85 | GRM5 (0.46) | HCRTR1HCRTR2SCD5GRM5 | |
| SCHEMBL2890825 | 0.85 | GRM5 (0.46) | HCRTR1HCRTR2SCD5GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007130821-A2 | MGLUR5 MODULATORS II | ASTRAZENECA AB (SE) | 2007-11-15 | — | — | WO | disclosed |