SCHEMBL8229485

SCHEMBL8229485

CCOCCN(C(=O)c1ccc2oc(NCc3cccc(Cl)c3)nc2c1)C1CCCC1

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRB P10828 18/20 0.60
HSD11B1 P28845 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8225995 0.88 THRB (0.62) THRBHSD11B1
SCHEMBL8220958 0.88 THRB (0.56) THRBHSD11B1
SCHEMBL8228011 0.87 THRB (0.59) THRBHSD11B1
SCHEMBL8225963 0.87 THRB (0.58) THRBHSD11B1
SCHEMBL5364060 0.87 THRB (0.60) THRBHSD11B1
SCHEMBL8225187 0.86 THRB (0.59) THRBHSD11B1
SCHEMBL8228557 0.86 THRB (0.58) THRB
SCHEMBL5363388 0.85 THRB (0.58) THRBHSD11B1
SCHEMBL8225249 0.85 THRB (0.57) THRBHSD11B1
SCHEMBL8227347 0.85 THRB (0.58) THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007140982-A1 SUBSTITUTED BENZOXAZOLES BAYER HEALTHCARE AG (DE) 2007-12-13 WO disclosed