Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 9/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL90402 | 0.92 | REN (0.52) | RENCYP1A2CYP2C9CYP2C19USP2 | |
| SCHEMBL89214 | 0.89 | REN (0.47) | RENCYP1A2CYP2C9CYP2C19USP2 | |
| SCHEMBL1911416 | 0.89 | REN (0.39) | RENCYP1A2CYP2C9CYP2C19USP2 | |
| SCHEMBL1911403 | 0.88 | REN (0.49) | RENCYP1A2CYP2C9CYP2C19USP2 | |
| SCHEMBL1911400 | 0.87 | REN (0.48) | RENCYP1A2CYP2C9CYP2C19USP2 | |
| SCHEMBL90313 | 0.85 | REN (0.61) | RENKMT2APOLB | |
| SCHEMBL89873 | 0.85 | REN (0.59) | RENKMT2APOLB | |
| SCHEMBL89495 | 0.85 | REN (0.63) | RENKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL89842 | 0.83 | REN (0.70) | REN | |
| SCHEMBL1911405 | 0.83 | REN (0.70) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007077005-A1 | 3 , 5-SUBSTITΓUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |