Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 14/20 | 0.51 |
| ▸ | NAMPT | P43490 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8225899 | 0.77 | CACNA1H (0.52) | CACNA1HPOLBCSNK1EJAK2JAK1 | |
| SCHEMBL8224611 | 0.77 | CACNA1H (0.49) | CACNA1H | |
| SCHEMBL8224073 | 0.76 | CACNA1H (0.60) | CACNA1H | |
| SCHEMBL13595944 | 0.67 | CACNA1H (1.00) | CACNA1H | |
| SCHEMBL8224871 | 0.67 | CACNA1H (0.62) | CACNA1HNAMPT | |
| SCHEMBL27503165 | 0.66 | GAA (0.46) | POLBCSNK1E | |
| SCHEMBL13595951 | 0.65 | CACNA1H (0.79) | CACNA1H | |
| SCHEMBL13595961 | 0.65 | CACNA1H (0.67) | CACNA1H | |
| SCHEMBL8218861 | 0.64 | CACNA1H (0.70) | CACNA1H | |
| SCHEMBL8225775 | 0.64 | CACNA1H (0.83) | CACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033460-A2 | TREATING PAIN, DIABETES, AND LIPID METABOLISM DISORDERS | SCHERING CORPORATION (US) | 2008-03-20 | — | — | WO | disclosed |