Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 16/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL89586 | 0.97 | REN (0.53) | RENALDH1A1POLBKCNH2MEN1 | |
| SCHEMBL89598 | 0.96 | REN (0.52) | RENALDH1A1POLB | |
| SCHEMBL8229874 | 0.96 | REN (0.52) | RENALDH1A1POLB | |
| SCHEMBL1911371 | 0.94 | REN (0.54) | RENALDH1A1POLBKCNH2 | |
| SCHEMBL89960 | 0.94 | REN (0.54) | RENALDH1A1POLBKCNH2 | |
| SCHEMBL90121 | 0.93 | REN (0.52) | RENALDH1A1KCNH2 | |
| SCHEMBL1911401 | 0.92 | REN (0.51) | RENALDH1A1KCNH2 | |
| SCHEMBL90038 | 0.92 | REN (0.51) | RENALDH1A1KCNH2 | |
| SCHEMBL90101 | 0.91 | REN (0.55) | RENALDH1A1POLBCYP3A4KCNH2 | |
| SCHEMBL10283288 | 0.90 | REN (0.50) | RENALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007077005-A1 | 3 , 5-SUBSTITΓUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |