Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 0.77 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.77 |
| ▸ | MMP3 | P08254 | 2/20 | 0.77 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | CCR4 | P51679 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 2/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | FPR3 | P25089 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10167938 | 0.90 | MMP13 (0.76) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL10161880 | 0.87 | MMP13 (0.90) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL8255038 | 0.87 | MMP13 (1.00) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL10210491 | 0.86 | MMP13 (0.88) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL10161938 | 0.86 | MMP13 (0.88) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL10162001 | 0.85 | MMP13 (0.86) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL10211461 | 0.85 | MMP13 (0.83) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL10210611 | 0.85 | MMP13 (0.88) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL13161130 | 0.85 | MMP13 (0.85) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL10161927 | 0.85 | MMP13 (0.85) | MMP13ADAMTS4MMP3MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007139856-A2 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS, INC. (US) | 2007-12-06 | — | — | WO | disclosed |