Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.45 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.37 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4915590 | 0.78 | BACE1 (0.65) | BACE1BACE2 | |
| SCHEMBL4892604 | 0.78 | BACE1 (0.65) | BACE1BACE2 | |
| SCHEMBL8185985 | 0.63 | BACE1 (0.60) | BACE1BACE2 | |
| SCHEMBL8177264 | 0.62 | BACE1 (0.59) | BACE1BACE2 | |
| SCHEMBL8192548 | 0.62 | BACE1 (0.58) | BACE1BACE2 | |
| SCHEMBL4883545 | 0.62 | BACE1 (0.67) | BACE1BACE2 | |
| SCHEMBL4884550 | 0.59 | BACE1 (0.88) | BACE1BACE2 | |
| SCHEMBL4884916 | 0.58 | BACE1 (1.00) | BACE1BACE2 | |
| SCHEMBL8225650 | 0.58 | BACE1 (0.73) | BACE1BACE2 | |
| SCHEMBL4887800 | 0.57 | BACE1 (0.71) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007145571-A9 | AMINO-IMIDAZOLONES AND THEIR USE AS A MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT, ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | WO | disclosed |