Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | GFER | P55789 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | CASP6 | P55212 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3440160 | 0.94 | GFER (0.74) | MAPTALDH1A1GFERSMN1; SMN2CASP6 | |
| SCHEMBL20354370 | 0.93 | GFER (0.72) | MAPTALDH1A1GFERSMN1; SMN2CASP6 | |
| SCHEMBL13832680 | 0.85 | SMN1; SMN2 (0.89) | MAPTALDH1A1GFERSMN1; SMN2GAA | |
| SCHEMBL13832674 | 0.84 | ALDH1A1 (0.71) | MAPTALDH1A1GFERSMN1; SMN2GAA | |
| SCHEMBL19294333 | 0.84 | SMN1; SMN2 (0.86) | MAPTALDH1A1GFERSMN1; SMN2GAA | |
| SCHEMBL188832 | 0.81 | AKR1C3 (0.65) | MAPTALDH1A1GFERSMN1; SMN2CASP6 | |
| SCHEMBL15650594 | 0.81 | GFER (0.65) | MAPTALDH1A1GFERSMN1; SMN2CASP6 | |
| SCHEMBL1813106 | 0.80 | GFER (0.68) | MAPTALDH1A1GFERSMN1; SMN2CASP6 | |
| SCHEMBL4985735 | 0.79 | AKR1C3 (0.68) | MAPTALDH1A1GFERSMN1; SMN2CASP6 | |
| SCHEMBL17076742 | 0.79 | MAPT (0.53) | MAPTALDH1A1GFERSMN1; SMN2CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |