Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 15/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2332701 | 0.89 | HTR4 (0.51) | HTR4ACHECYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL5631883 | 0.89 | HTR4 (0.50) | HTR4ACHECYP3A4CYP2D6 | |
| Succinic Acid SCHEMBL5632076 | 0.85 | HTR4 (0.47) | HTR4ACHECYP3A4CYP2D6 | |
| SCHEMBL2331750 | 0.84 | HTR4 (0.53) | HTR4ACHEHTR3EHTR3BHTR3A | |
| SCHEMBL2333431 | 0.84 | HTR4 (0.53) | HTR4ACHEHTR3EHTR3BHTR3A | |
| SCHEMBL2331760 | 0.84 | HTR4 (0.53) | HTR4ACHEHTR3EHTR3BHTR3A | |
| Hydrochloric Acid SCHEMBL5332277 | 0.83 | HTR4 (0.47) | HTR4ACHEHTR3EHTR3BHTR3A | |
| Hydrochloric Acid SCHEMBL5316450 | 0.83 | HTR4 (0.53) | HTR4ACHEHTR3EHTR3BHTR3A | |
| SCHEMBL5630511 | 0.80 | HTR4 (0.45) | HTR4ACHECYP3A4CYP2D6MEN1 | |
| SCHEMBL2329530 | 0.79 | HTR4 (0.51) | HTR4ACHEALDH1A1HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007096352-A1 | 5-AMINO-6-BROMO-N-{ [1- (TETRAHYDR0-2H-PYRAN-4-YLMETHYL) -4-PIPERIDINYL] METHYL}-3, 4 -DIHYDRO-2H-CHROMENE-8-CARBOXAMIDE AS 5-HT4 RECEPTOR AGONIST | GLAXO GROUP LIMITED (GB) | 2007-08-30 | — | — | WO | disclosed |