Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.65 |
| ▸ | MAPT | P10636 | 11/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | PPARG | P37231 | 1/20 | 0.61 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.61 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 4/20 | 0.59 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12417212 | 0.90 | MAPT (0.63) | KMT2AMAPTALDH1A1MEN1KDM4E | |
| SCHEMBL12417165 | 0.82 | MAPT (0.66) | KMT2AMAPTALDH1A1MEN1KDM4E | |
| SCHEMBL12417160 | 0.79 | MAPT (0.60) | KMT2AMAPTALDH1A1MEN1KDM4E | |
| SCHEMBL11913670 | 0.75 | MAPT (0.58) | KMT2AMAPTALDH1A1MEN1KDM4E | |
| SCHEMBL12443073 | 0.75 | KMT2A (0.74) | KMT2AMAPTALDH1A1MEN1KDM4E | |
| SCHEMBL12417208 | 0.74 | MAPT (0.59) | KMT2AMAPTALDH1A1MEN1KDM4E | |
| SCHEMBL8239208 | 0.74 | HTT (0.71) | KMT2AMAPTALDH1A1MEN1KDM4E | |
| SCHEMBL12417173 | 0.73 | MAPT (0.56) | KMT2AMAPTALDH1A1MEN1KDM4E | |
| SCHEMBL11918204 | 0.73 | MAPT (0.51) | KMT2AMAPTALDH1A1MEN1KDM4E | |
| SCHEMBL6721129 | 0.72 | MAPT (0.65) | KMT2AMAPTALDH1A1MEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1790345-A1 | Triazin beta-secretase inhibitors | Esbatech AG (CH) | 2007-05-30 | — | — | EP | disclosed |
| WO-2007051333-A1 | TRIAZINE BETA-SECRETASE INHIBITORS | ONCALIS AG (CH) | 2007-05-10 | — | — | WO | disclosed |