Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2B6 | P20813 | 1/20 | 0.61 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19614353 | 0.81 | CYP2B6 (0.61) | CYP2B6CHRM3CHRM2ATML3MBTL1 | |
| SCHEMBL3760488 | 0.81 | CHRM3 (0.45) | CYP2B6CHRM3CHRM2CHRM1OPRL1 | |
| SCHEMBL28067245 | 0.78 | CYP19A1 (0.43) | CYP2B6 | |
| SCHEMBL30364035 | 0.78 | CYP2B6 (0.88) | CYP2B6CHRM3CHRM2CHRM1GRIN2D | |
| SCHEMBL19011533 | 0.78 | CYP2B6 (0.96) | CYP2B6CHRM3CHRM2CHRM1GRIN2D | |
| SCHEMBL17513237 | 0.78 | CHRM2 (0.43) | CYP2B6CHRM3CHRM2CHRM1KCNH2 | |
| SCHEMBL11398380 | 0.76 | CYP2B6 (1.00) | CYP2B6CHRM3CHRM2CHRM1OPRM1 | |
| SCHEMBL2697745 | 0.76 | CYP2B6 (1.00) | CYP2B6CHRM3CHRM2CHRM1OPRM1 | |
| SCHEMBL25533428 | 0.76 | CYP2B6 (0.70) | CYP2B6CHRM2CHRM1GRIN2DGRIN3B | |
| Tert-Butylbenzene SCHEMBL26616626 | 0.76 | TAAR1 (0.43) | CHRM3CHRM2CHRM1OPRL1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007106525-A1 | PIPERIDINYL, INDOLYL, PIRINIDYL, MORPHOLINYL AND BENZIMIDAZOLYL UREA DERIVATIVES AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE FOR THE TREATMENT OF HYPERTENSION, INFLAMMATIONS AND OTHER DISEASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-09-20 | — | — | WO | disclosed |