Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 3/20 | 0.64 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.64 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.54 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.54 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.54 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.54 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.54 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.49 |
| ▸ | CMA1 | P23946 | 2/20 | 0.44 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14280941 | 0.86 | KCNA3 (0.60) | KCNA3KCNN4PSEN1PSEN2APH1B | |
| SCHEMBL3041480 | 0.79 | KCNA3 (1.00) | KCNA3KCNN4PSEN1PSEN2APH1B | |
| SCHEMBL14280956 | 0.76 | KCNA3 (0.59) | KCNA3KCNN4PSEN1PSEN2APH1B | |
| SCHEMBL28973111 | 0.75 | KCNN4 (0.62) | KCNA3KCNN4MEN1KMT2AMMP2 | |
| SCHEMBL29754844 | 0.75 | KCNN4 (0.62) | KCNA3KCNN4MEN1KMT2AMMP2 | |
| SCHEMBL8230676 | 0.74 | KCNA3 (0.48) | KCNA3KCNN4PSEN1PSEN2APH1B | |
| SCHEMBL2705507 | 0.73 | KMT2A (0.68) | KCNA3KCNN4PSEN1PSEN2APH1B | |
| SCHEMBL28973103 | 0.72 | MMP2 (0.47) | KCNA3KCNN4MEN1KMT2AMMP2 | |
| SCHEMBL29754785 | 0.72 | MMP2 (0.47) | KCNA3KCNN4MEN1KMT2AMMP2 | |
| SCHEMBL2702553 | 0.72 | KCNA3 (0.64) | KCNA3KCNN4PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007143523-A2 | FUSED, TRICYCLIC SULFONAMIDE INHIBITORS OF GAMMA SECRETASE | ELAN PHARMACEUTICALS, INC. (US) | 2007-12-13 | — | — | WO | disclosed |