Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | FAAH | O00519 | 3/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988297 | 0.92 | STIM1 (0.45) | ALDH1A1SMN1; SMN2AURKAMAPTKMT2A | |
| SCHEMBL987652 | 0.85 | LMNA (0.41) | SMN1; SMN2LMNA | |
| SCHEMBL987687 | 0.83 | MAPT (0.41) | ALDH1A1SMN1; SMN2MAPTKMT2ARAB9A | |
| SCHEMBL10104881 | 0.81 | MAPT (0.40) | ALDH1A1SMN1; SMN2MAPTKMT2ARAB9A | |
| SCHEMBL8232807 | 0.80 | ERN1 (0.41) | MAPTLMNAPOLBPTPN11 | |
| SCHEMBL987057 | 0.78 | CYP2D6 (0.41) | RAB9ACYP2D6POLBPTPN11 | |
| SCHEMBL986498 | 0.76 | STIM1 (0.50) | RAB9ANPC1LMNA | |
| SCHEMBL986996 | 0.74 | TYK2 (0.39) | ALDH1A1SMN1; SMN2MAPTKMT2ARAB9A | |
| SCHEMBL8228702 | 0.73 | PDGFRB (0.39) | ALDH1A1SMN1; SMN2MAPTKMT2ARAB9A | |
| SCHEMBL987577 | 0.73 | NAMPT (0.39) | ALDH1A1SMN1; SMN2MAPTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007087443-A2 | VINYL-PHENYL DERIVATIVES FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-08-02 | — | — | WO | disclosed |