Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.82 |
| ▸ | MAPT | P10636 | 2/20 | 0.82 |
| ▸ | HTT | P42858 | 1/20 | 0.82 |
| ▸ | GRM2 | Q14416 | 7/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.69 |
| ▸ | DRD4 | P21917 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4149145 | 0.90 | LMNA (0.79) | LMNASMN1; SMN2MAPTHTTGRM2 | |
| SCHEMBL12728853 | 0.85 | KDM4E (0.73) | LMNASMN1; SMN2MAPTHTTGRM2 | |
| SCHEMBL20371574 | 0.84 | KDM4E (0.68) | LMNASMN1; SMN2MAPTHTTGRM2 | |
| SCHEMBL4138559 | 0.84 | GRM2 (1.00) | LMNASMN1; SMN2MAPTHTTGRM2 | |
| SCHEMBL4152030 | 0.81 | GRM2 (0.75) | LMNASMN1; SMN2MAPTHTTGRM2 | |
| SCHEMBL4151932 | 0.80 | KDM4E (0.62) | LMNASMN1; SMN2MAPTHTTGRM2 | |
| SCHEMBL7523988 | 0.77 | GRM2 (0.52) | LMNASMN1; SMN2MAPTHTTGRM2 | |
| Bromide SCHEMBL7528105 | 0.76 | LMNA (0.51) | LMNASMN1; SMN2MAPTHTTGRM2 | |
| SCHEMBL4147946 | 0.75 | GRM2 (0.83) | LMNASMN1; SMN2MAPTHTTGRM2 | |
| SCHEMBL11749672 | 0.74 | HIF1A (0.79) | LMNASMN1; SMN2MAPTHTTGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007115077-A2 | BICYCLIC BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2007-10-11 | — | — | WO | disclosed |