Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 11/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.53 |
| ▸ | CHUK | O15111 | 1/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 8/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8233717 | 0.92 | IKBKB (0.53) | IKBKBMAPK8CHUKMAPK9MAPK10 | |
| SCHEMBL5310497 | 0.91 | IKBKB (0.46) | IKBKBMAPK8CHUKMAPK9MAPK10 | |
| SCHEMBL8235920 | 0.88 | IKBKB (0.49) | IKBKBMAPK8CHUKMAPK9MAPK10 | |
| SCHEMBL8227898 | 0.88 | IKBKB (0.60) | IKBKBMAPK8CHUKMAPK9MAPK10 | |
| SCHEMBL8233232 | 0.83 | IKBKB (0.48) | IKBKBMAPK8CHUKMAPK9MAPK10 | |
| SCHEMBL8233871 | 0.82 | IKBKB (0.47) | IKBKBMAPK8CHUKMAPK9MAPK10 | |
| SCHEMBL5309626 | 0.81 | BCDIN3D (0.46) | IKBKBMAPK8CHUKMAPK9MAPK10 | |
| SCHEMBL8235871 | 0.80 | CDK4 (0.58) | IKBKBMAPK8MAPK9MAPK10MAPK14 | |
| SCHEMBL8233031 | 0.79 | PIK3C3 (0.54) | MAPK8MAPK9MAPK10CDK2CCNA2 | |
| SCHEMBL8227901 | 0.78 | CDK4 (0.57) | IKBKBMAPK8CDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |