Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | VHL | P40337 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30914650 | 0.85 | KDM4A (0.42) | HDAC6HDAC1POLBKDM4ANR1H4 | |
| SCHEMBL1810190 | 0.84 | NR1H4 (0.45) | HDAC6HDAC1POLBKDM4ANR1H4 | |
| SCHEMBL4010124 | 0.83 | NR1H4 (0.44) | HDAC6HDAC1POLBKDM4ANR1H4 | |
| SCHEMBL27773505 | 0.83 | NR1H4 (0.47) | HDAC6HDAC1POLBKDM4ANR1H4 | |
| SCHEMBL4015367 | 0.83 | EPHX2 (0.52) | EPHX2HDAC6HDAC1KDM4ANR1H4 | |
| SCHEMBL2123367 | 0.83 | EPHX2 (0.41) | EPHX2HDAC6HDAC1KDM4ANR1H4 | |
| SCHEMBL1178054 | 0.82 | MAPT (0.43) | HDAC6HDAC1POLBKDM4ANR1H4 | |
| SCHEMBL3862171 | 0.82 | EPHX2 (0.53) | EPHX2KDM4ELMNANPC1RAB9A | |
| SCHEMBL9849328 | 0.81 | NR1H4 (0.43) | EPHX2HDAC6HDAC1KDM4ANR1H4 | |
| SCHEMBL3856479 | 0.80 | GFER (0.40) | EPHX2HDAC6HDAC1POLBKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090088452-A1 | Indole Orexin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2009-04-02 | — | — | US | disclosed |
| WO-2007061763-A2 | INDOLE OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088452-A1 | Indole Orexin Receptor Antagonists | HCRTR2, HCRTR1, OXTR | EPHX2 2029/4885VHL 575/4885HDAC6 781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.