Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL89792 | 0.94 | REN (0.49) | RENALDH1A1SMN1; SMN2KMT2APOLB | |
| SCHEMBL90061 | 0.90 | REN (0.46) | RENALDH1A1SMN1; SMN2KMT2APOLB | |
| SCHEMBL1911396 | 0.90 | REN (0.46) | RENALDH1A1SMN1; SMN2KMT2APOLB | |
| SCHEMBL89924 | 0.90 | REN (0.47) | RENALDH1A1SMN1; SMN2KMT2APOLB | |
| SCHEMBL89971 | 0.89 | REN (0.55) | RENALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL90631 | 0.87 | REN (0.41) | RENALDH1A1SMN1; SMN2KMT2APOLB | |
| SCHEMBL90629 | 0.87 | REN (0.39) | RENALDH1A1SMN1; SMN2KMT2APOLB | |
| SCHEMBL8229895 | 0.87 | REN (0.55) | RENALDH1A1SMN1; SMN2KMT2APOLB | |
| SCHEMBL89536 | 0.87 | REN (0.44) | RENALDH1A1SMN1; SMN2KMT2APOLB | |
| SCHEMBL89114 | 0.86 | REN (0.47) | RENALDH1A1SMN1; SMN2KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007077005-A1 | 3 , 5-SUBSTITΓUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |