Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | REN | P00797 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1911383 | 1.00 | TSHR (0.46) | TSHRRENKDM4EPOLBTP53 | |
| SCHEMBL90394 | 0.88 | REN (0.52) | TSHRRENKDM4EPOLBTP53 | |
| SCHEMBL89189 | 0.88 | REN (0.52) | TSHRRENKDM4EPOLBTP53 | |
| SCHEMBL8234873 | 0.88 | REN (0.45) | TSHRRENPOLBTP53MAPT | |
| SCHEMBL89197 | 0.87 | REN (0.45) | TSHRRENKDM4EPOLBTP53 | |
| SCHEMBL89698 | 0.87 | TSHR (0.42) | TSHRRENKDM4EPOLBTP53 | |
| SCHEMBL90623 | 0.87 | REN (0.47) | TSHRRENTP53THRB | |
| SCHEMBL90326 | 0.86 | REN (0.55) | TSHRREN | |
| SCHEMBL1911355 | 0.85 | REN (0.43) | TSHRRENKDM4EPOLBTP53 | |
| SCHEMBL90025 | 0.85 | TSHR (0.41) | TSHRRENKDM4EPOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007077005-A1 | 3 , 5-SUBSTITΓUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |