SCHEMBL8235657

SCHEMBL8235657

CC(C)(C)OC(=O)N1CCN(C(=O)c2ncn(CC3(O)CCCN(S(C)(=O)=O)C3)c2-c2ccccc2)[C@H](Cc2ccccc2)C1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ABHD6 Q9BV23 1/20 0.41
DAGLA Q9Y4D2 1/20 0.41
NR1H2 P55055 2/20 0.39
NR1H3 Q13133 2/20 0.39
PARP1 P09874 1/20 0.37
CA1 P00915 12/20 0.37
CA2 P00918 12/20 0.37
CA4 P22748 12/20 0.37
CA9 Q16790 12/20 0.37
DPP4 P27487 1/20 0.36
OPRD1 P41143 1/20 0.34
OPRK1 P41145 1/20 0.34
USP19 O94966 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
TSHR P16473 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8231279 0.93 ABHD6 (0.40) ABHD6DAGLANR1H2NR1H3PARP1
SCHEMBL8229767 0.92 ABHD6 (0.43) ABHD6DAGLANR1H2NR1H3PARP1
SCHEMBL3495527 0.91 CA1 (0.40) CA1CA2CA4CA9CYP3A4
SCHEMBL4978691 0.89 ABHD6 (0.42) ABHD6DAGLANR1H2NR1H3PARP1
SCHEMBL13341121 0.89 ABHD6 (0.42) ABHD6DAGLANR1H2NR1H3PARP1
SCHEMBL8236501 0.86 ABHD6 (0.42) ABHD6DAGLANR1H2NR1H3PARP1
SCHEMBL8238575 0.86 ABHD6 (0.42) ABHD6DAGLANR1H2NR1H3PARP1
SCHEMBL8237203 0.85 ABHD6 (0.44) ABHD6DAGLANR1H2NR1H3PARP1
SCHEMBL8235940 0.85 ABHD6 (0.44) ABHD6DAGLANR1H2NR1H3PARP1
SCHEMBL8238147 0.85 ABHD6 (0.43) ABHD6DAGLANR1H2NR1H3PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007094513-A2 CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-08-23 WO disclosed