Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 11/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | STS | P08842 | 1/20 | 0.32 |
| ▸ | UBE2M | P61081 | 1/20 | 0.31 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.31 |
| ▸ | CETP | P11597 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL90335 | 0.94 | REN (0.43) | RENALDH1A1LMNAKCNH2TSHR | |
| SCHEMBL89244 | 0.91 | REN (0.43) | RENALDH1A1LMNATSHRMEN1 | |
| SCHEMBL8239216 | 0.90 | REN (0.39) | RENALDH1A1LMNAKCNH2TSHR | |
| SCHEMBL8234922 | 0.89 | REN (0.45) | RENALDH1A1LMNAKCNH2 | |
| SCHEMBL89276 | 0.89 | REN (0.40) | RENALDH1A1LMNAKCNH2TSHR | |
| SCHEMBL89207 | 0.89 | REN (0.46) | RENALDH1A1LMNAKCNH2 | |
| SCHEMBL89092 | 0.89 | REN (0.46) | RENALDH1A1LMNAKCNH2 | |
| SCHEMBL89204 | 0.87 | REN (0.44) | RENALDH1A1LMNAKCNH2 | |
| SCHEMBL89266 | 0.86 | REN (0.42) | RENALDH1A1LMNAKCNH2TSHR | |
| SCHEMBL89614 | 0.85 | REN (0.44) | RENALDH1A1LMNAKCNH2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007077005-A1 | 3 , 5-SUBSTITΓUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |