Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.74 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.74 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.74 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.74 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.74 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.74 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.74 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.74 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.74 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.74 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.74 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.62 |
| ▸ | RELA | Q04206 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27967111 | 0.98 | HDAC1 (0.72) | HDAC1HDAC2HDAC3HDAC6HDAC10 | |
| SCHEMBL4396208 | 0.87 | MAPT (0.64) | HDAC1HDAC2HDAC3HDAC6HDAC10 | |
| SCHEMBL22871621 | 0.84 | HDAC3 (0.73) | HDAC1HDAC2HDAC3HDAC6HDAC10 | |
| SCHEMBL17826588 | 0.84 | SIRT2 (0.63) | — | |
| SCHEMBL16016606 | 0.84 | HDAC1 (0.74) | HDAC1HDAC2HDAC3HDAC6HDAC10 | |
| SCHEMBL14147975 | 0.83 | HDAC1 (0.73) | HDAC1HDAC2HDAC3HDAC6HDAC10 | |
| SCHEMBL10362398 | 0.81 | HDAC1 (0.68) | HDAC1HDAC2HDAC3HDAC6HDAC10 | |
| SCHEMBL7813937 | 0.81 | MAPT (0.69) | HDAC1HDAC2HDAC3HDAC6HDAC10 | |
| SCHEMBL7373555 | 0.81 | HDAC1 (0.68) | HDAC1HDAC2HDAC3HDAC6HDAC10 | |
| SCHEMBL23798902 | 0.80 | HDAC3 (0.72) | HDAC1HDAC2HDAC3HDAC6HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200439-B1 | HDAC INHIBITORS | LIXTE BIOTECHNOLOGY INC (US) | 2017-03-22 | — | — | EP | disclosed |
| US-8143445-B2 | HDAC inhibitors | LIXTE BIOTECHNOLOGY, INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-20090143445-A1 | HDAC Inhibitors | JOHN P. WHITE, ESQ | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143445-A1 | HDAC Inhibitors | HDAC3, HDAC7, HDAC4 | HDAC1 6/4885HDAC2 8/4885HDAC3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.