Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1911398 | 1.00 | REN (0.44) | RENKCNH2CYP3A4SSTR4 | |
| SCHEMBL89657 | 1.00 | REN (0.44) | RENKCNH2CYP3A4SSTR4 | |
| SCHEMBL89153 | 0.86 | REN (0.34) | RENKCNH2CYP3A4 | |
| SCHEMBL89758 | 0.79 | REN (0.51) | RENKCNH2CYP3A4 | |
| SCHEMBL8238285 | 0.79 | REN (0.51) | RENKCNH2CYP3A4 | |
| SCHEMBL89468 | 0.78 | REN (0.72) | RENKCNH2 | |
| SCHEMBL89261 | 0.78 | REN (0.61) | RENKCNH2 | |
| SCHEMBL8235595 | 0.78 | REN (0.52) | RENKCNH2CYP3A4SSTR4 | |
| SCHEMBL90113 | 0.78 | REN (0.52) | RENKCNH2CYP3A4SSTR4 | |
| SCHEMBL89939 | 0.76 | REN (0.44) | RENKCNH2CYP3A4SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007077005-A1 | 3 , 5-SUBSTITΓUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |