Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8236807 | 0.97 | REN (0.68) | RENKCNH2MEN1ALDH1A1KMT2A | |
| SCHEMBL90376 | 0.96 | REN (0.69) | RENKCNH2MEN1ALDH1A1KMT2A | |
| SCHEMBL90323 | 0.96 | REN (0.69) | RENKCNH2MEN1ALDH1A1KMT2A | |
| SCHEMBL90363 | 0.96 | REN (0.65) | RENKCNH2MEN1ALDH1A1KMT2A | |
| SCHEMBL89730 | 0.95 | REN (0.70) | RENKCNH2MEN1ALDH1A1KMT2A | |
| SCHEMBL90037 | 0.94 | REN (0.72) | RENKCNH2 | |
| SCHEMBL90053 | 0.94 | REN (0.72) | RENKCNH2 | |
| SCHEMBL89140 | 0.94 | REN (0.72) | RENKCNH2 | |
| SCHEMBL90217 | 0.94 | REN (0.72) | RENKCNH2 | |
| SCHEMBL90458 | 0.93 | REN (0.68) | RENKCNH2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007077005-A1 | 3 , 5-SUBSTITΓUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |