Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | BUB1 | O43683 | 1/20 | 0.37 |
| ▸ | VCP | P55072 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8234082 | 0.86 | MAPK1 (0.40) | JAK3CCNT1CDK9CCNA2CDK2 | |
| SCHEMBL5313196 | 0.81 | ADORA2A (0.46) | BCDIN3DCCNT1CCNA2CDK2CCNA1 | |
| SCHEMBL8236676 | 0.78 | CDK2 (0.41) | VCPCCNA2CDK2PIK3CD | |
| SCHEMBL3652082 | 0.76 | JAK2 (0.49) | JAK3NAMPTJAK2BUB1VCP | |
| SCHEMBL5309626 | 0.76 | BCDIN3D (0.46) | BCDIN3DJAK3JAK2VCPCDK2 | |
| SCHEMBL8233813 | 0.73 | IRAK1 (0.43) | BCDIN3DIRAK1CCNT1VCPCCNA2 | |
| SCHEMBL8233720 | 0.71 | CDK2 (0.47) | CCNA2CDK2CCNA1 | |
| SCHEMBL8233534 | 0.71 | CXCR4 (0.44) | BCDIN3DCDK2 | |
| SCHEMBL8235923 | 0.70 | MKNK1 (0.43) | JAK2CCNT1CDK9CDK2SYK | |
| SCHEMBL26506937 | 0.69 | GRIN2B (0.47) | BCDIN3DVCPGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |