Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD4 | P21917 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8236173 | 0.84 | SMN1; SMN2 (0.38) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL2034294 | 0.77 | ALDH1A3 (0.45) | MAPTCYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL8236368 | 0.77 | CYP2C9 (0.54) | NPC1RAB9AMAPTCYP1A2CYP2C9 | |
| SCHEMBL8233686 | 0.77 | TRIM24 (0.42) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL8235484 | 0.75 | NR4A2 (0.56) | NPC1RAB9AMAPTCYP1A2CYP2C9 | |
| SCHEMBL8228445 | 0.75 | NR4A2 (0.56) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL2027826 | 0.75 | NR4A2 (0.56) | — | |
| SCHEMBL8240896 | 0.74 | CYP2C9 (0.38) | NPC1RAB9AMAPTCYP1A2CYP2C9 | |
| SCHEMBL8233967 | 0.74 | KDM4E (0.34) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL14634108 | 0.74 | NR4A2 (0.37) | NPC1RAB9AMAPTCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477990-A1 | 5-PHENYL PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-07-25 | — | — | EP | disclosed |
| WO-2011033230-A1 | 5-PHENYL PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-03-24 | — | — | WO | disclosed |