Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 16/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL823701 | 0.87 | HDAC1 (0.60) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL823581 | 0.86 | HDAC3 (0.59) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL3628927 | 0.83 | HDAC1 (0.69) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL823572 | 0.78 | HDAC3 (0.58) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL10789563 | 0.74 | HPGD (0.78) | ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL14627718 | 0.74 | HDAC8 (0.62) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL823580 | 0.72 | HDAC1 (0.74) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL823655 | 0.72 | HDAC4 (0.65) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL1367030 | 0.72 | HDAC1 (1.00) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL823656 | 0.72 | HDAC4 (0.65) | HDAC3HDAC1HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143445-B2 | HDAC inhibitors | LIXTE BIOTECHNOLOGY, INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-20090143445-A1 | HDAC Inhibitors | JOHN P. WHITE, ESQ | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143445-A1 | HDAC Inhibitors | HDAC3, HDAC7, HDAC4 | HDAC3 1/4885HDAC1 6/4885HDAC4 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.