Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14364305 | 0.85 | HSD17B10 (0.65) | ALDH1A1HSD17B10MTNR1AMTNR1B | |
| SCHEMBL19143523 | 0.81 | CLK1 (0.40) | ALDH1A1HSD17B10CLK1DYRK1ADYRK1B | |
| SCHEMBL8237110 | 0.78 | HSD17B10 (0.50) | ALDH1A1HSD17B10PTGS1AKR1C3AKR1C2 | |
| SCHEMBL12431134 | 0.76 | HSD17B10 (0.48) | HSD17B10POLB | |
| SCHEMBL1708481 | 0.76 | HTT (0.56) | ALDH1A1POLBALOX5KDM4EHTT | |
| SCHEMBL16929973 | 0.75 | KDM4E (0.41) | ALDH1A1AKR1C3AKR1C2KDM4ENPC1 | |
| SCHEMBL11948699 | 0.75 | MAPT (0.58) | ALDH1A1POLBKDM4ELMNAHPGD | |
| SCHEMBL13980506 | 0.75 | NPC1 (0.54) | HSD17B10HSP90AA1NPC1LMNAHTT | |
| SCHEMBL904249 | 0.74 | SIGMAR1 (0.57) | ALDH1A1POLBHTTMTNR1AMTNR1B | |
| SCHEMBL9112759 | 0.73 | MAPT (0.38) | ALDH1A1CLK1DYRK1ADYRK1BALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007087427-A2 | THIAZOLE AND THIADIAZOLE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-08-02 | — | — | WO | disclosed |