Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 2/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 3/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4329871 | 0.88 | PIK3CG (0.60) | PIK3CGCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8238604 | 0.86 | PIK3CG (0.42) | PIK3CGCYP11B1CYP11B2CYP1A2 | |
| SCHEMBL4327454 | 0.78 | PIK3CG (0.50) | PIK3CGCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL4972615 | 0.78 | PIK3CG (0.38) | PIK3CGCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL4327904 | 0.75 | PIK3CG (0.53) | PIK3CGCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL8237379 | 0.74 | PIK3CG (0.52) | PIK3CGCYP11B1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8235630 | 0.74 | PIK3CG (0.54) | PIK3CGCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4323406 | 0.74 | PIK3CG (0.56) | PIK3CGCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL4323390 | 0.74 | PIK3CG (0.51) | PIK3CGCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL4331435 | 0.74 | PIK3CG (0.51) | PIK3CGCYP11B1CYP11B2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007095024-A1 | METABOTROPIC GLUTAMATE RECEPTOR-POTENTIATING ΓSOINDOLONES | ASTRAZENECA AB (SE) | 2007-08-23 | — | — | WO | disclosed |