Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 3/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 12/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 11/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4331435 | 0.87 | PIK3CG (0.51) | PIK3CGCYP11B1CYP11B2CYP1A2 | |
| SCHEMBL8237389 | 0.86 | PIK3CG (0.47) | PIK3CGCYP11B1CYP11B2CYP1A2 | |
| SCHEMBL4340756 | 0.81 | PIK3CG (0.50) | PIK3CGCYP11B1CYP11B2CYP1A2 | |
| SCHEMBL4323390 | 0.79 | PIK3CG (0.51) | PIK3CGCYP11B1CYP11B2CYP1A2 | |
| SCHEMBL4327904 | 0.78 | PIK3CG (0.53) | PIK3CGCYP11B1CYP11B2CYP1A2 | |
| SCHEMBL8237379 | 0.75 | PIK3CG (0.52) | PIK3CGCYP11B1CYP1A2 | |
| SCHEMBL8235630 | 0.75 | PIK3CG (0.54) | PIK3CGCYP1A2 | |
| SCHEMBL4323406 | 0.75 | PIK3CG (0.56) | PIK3CGCYP11B1CYP11B2CYP1A2CYP17A1 | |
| SCHEMBL8237383 | 0.75 | PIK3CG (0.51) | PIK3CGCYP11B1CYP11B2CYP1A2 | |
| SCHEMBL4327454 | 0.74 | PIK3CG (0.50) | PIK3CGCYP11B1CYP11B2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007095024-A1 | METABOTROPIC GLUTAMATE RECEPTOR-POTENTIATING ΓSOINDOLONES | ASTRAZENECA AB (SE) | 2007-08-23 | — | — | WO | disclosed |