Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL89616 | 0.92 | REN (0.53) | RENALDH1A1TDP1CYP1A2CYP2C9 | |
| SCHEMBL90241 | 0.91 | REN (0.49) | RENALDH1A1SSTR4GAATDP1 | |
| SCHEMBL8229861 | 0.87 | REN (0.36) | RENSCN9AALDH1A1TDP1CYP1A2 | |
| SCHEMBL89679 | 0.85 | REN (0.47) | RENALDH1A1SSTR4TDP1CYP1A2 | |
| SCHEMBL90208 | 0.84 | REN (0.56) | RENTDP1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8235471 | 0.84 | REN (0.56) | RENTDP1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL90491 | 0.83 | REN (0.46) | RENALDH1A1TDP1CYP1A2CYP2C9 | |
| SCHEMBL8238499 | 0.82 | REN (0.59) | RENALDH1A1MEN1KMT2A | |
| SCHEMBL8235599 | 0.82 | REN (0.45) | RENSCN9AALDH1A1GAAMEN1 | |
| SCHEMBL8238346 | 0.82 | REN (0.54) | RENALDH1A1GAATDP1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007077005-A1 | 3 , 5-SUBSTITΓUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |