Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 7/20 | 0.65 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16681578 | 0.79 | ATM (0.68) | P4HTMATMABCB1SMN1; SMN2MEN1 | |
| SCHEMBL8235500 | 0.79 | PLAU (1.00) | PLAU | |
| SCHEMBL8237950 | 0.78 | PLAU (0.65) | PLAUSMN1; SMN2 | |
| SCHEMBL16675161 | 0.76 | ABCB1 (0.68) | P4HTMATMABCB1SMN1; SMN2MEN1 | |
| SCHEMBL16675167 | 0.76 | ABCB1 (0.68) | P4HTMATMABCB1SMN1; SMN2MEN1 | |
| SCHEMBL8235966 | 0.76 | PLAU (0.59) | PLAUMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8229664 | 0.76 | PLAU (0.72) | PLAUSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8235561 | 0.75 | PLAU (0.87) | PLAU | |
| SCHEMBL4841395 | 0.75 | PLAU (0.54) | PLAULMNAMAPTGFER | |
| SCHEMBL5591691 | 0.74 | PLAU (0.84) | PLAUKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007072041-A1 | THERAPEUTIC COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2007-06-28 | — | — | WO | disclosed |