Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 10/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8235964 | 0.82 | PLAU (0.85) | PLAUKDM4ETAS1R3TAS1R1TAS1R2 | |
| SCHEMBL8235458 | 0.82 | PLAU (0.65) | PLAUTAS1R3TAS1R1TAS1R2MEN1 | |
| SCHEMBL4841395 | 0.80 | PLAU (0.54) | PLAUKDM4EPOLBTDP1MAPT | |
| Hydrochloric Acid SCHEMBL4841382 | 0.79 | PLAU (0.53) | PLAUKDM4EPOLBTDP1MAPT | |
| SCHEMBL15662729 | 0.78 | KDM4E (0.44) | PLAUKDM4EPOLBTDP1MAPT | |
| SCHEMBL8238849 | 0.78 | PLAU (0.88) | PLAUPOLBMEN1KMT2ANPC1 | |
| SCHEMBL8235777 | 0.77 | PLAU (0.91) | PLAUKMT2ANPC1RAB9AMAPT | |
| SCHEMBL8237977 | 0.76 | PLAU (0.65) | PLAUMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8235965 | 0.76 | PLAU (0.54) | PLAU | |
| SCHEMBL8238851 | 0.76 | PLAU (0.52) | PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007072041-A1 | THERAPEUTIC COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2007-06-28 | — | — | WO | disclosed |