Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 12/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 9/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 9/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 9/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 9/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12147391 | 1.00 | APP (0.37) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1362865 | 0.85 | CYP3A4 (0.37) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1362862 | 0.85 | CYP3A4 (0.37) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1362866 | 0.85 | CYP3A4 (0.37) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8237900 | 0.83 | MMP2 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1362927 | 0.79 | PSEN1 (0.33) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14461137 | 0.74 | MEN1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12147220 | 0.74 | MEN1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8231928 | 0.74 | CYP3A4 (0.41) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1362802 | 0.74 | CYP3A4 (0.41) | APPPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007084595-A2 | CARBOCYCLIC AND HETEROCYCLIC ARYLSULFONES AS GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2007-07-26 | — | — | WO | disclosed |