SCHEMBL8238567

SCHEMBL8238567

CCOC[C@@H](C)NC(=O)C1CNC[C@H](C(=O)N(c2ccc3c(c2)N(CCCOC)C(=O)C(C)(C)O3)C2CC2)C1

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
REN P00797 20/20 0.70
KCNH2 Q12809 5/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL90690 1.00 REN (0.70) RENKCNH2
SCHEMBL89930 1.00 REN (0.70) RENKCNH2
SCHEMBL8238502 1.00 REN (0.70) RENKCNH2
SCHEMBL89876 0.95 REN (0.67) RENKCNH2
SCHEMBL89309 0.95 REN (0.67) RENKCNH2
SCHEMBL89328 0.95 REN (0.65) RENKCNH2
SCHEMBL90277 0.95 REN (0.65) RENKCNH2
SCHEMBL90004 0.94 REN (0.61) RENKCNH2
SCHEMBL89412 0.94 REN (0.64) RENKCNH2
SCHEMBL89431 0.94 REN (0.64) RENKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007077005-A1 3 , 5-SUBSTITΓUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS NOVARTIS AG (CH) 2007-07-12 WO disclosed