Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 14/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1196478 | 0.85 | F11 (0.52) | F11KLKB1 | |
| SCHEMBL12011591 | 0.84 | F11 (0.55) | F11NPC1RAB9ASMN1; SMN2KLKB1 | |
| SCHEMBL1197509 | 0.79 | F11 (0.52) | F11SMN1; SMN2KLKB1 | |
| SCHEMBL1197513 | 0.79 | F11 (0.52) | F11SMN1; SMN2KLKB1 | |
| SCHEMBL1197488 | 0.79 | F11 (0.50) | F11KLKB1 | |
| SCHEMBL1197333 | 0.79 | F11 (0.63) | F11NPC1RAB9ASMN1; SMN2KLKB1 | |
| SCHEMBL1197057 | 0.79 | F11 (0.63) | F11NPC1RAB9ASMN1; SMN2KLKB1 | |
| SCHEMBL4825968 | 0.75 | F11 (0.47) | F11KLKB1KMT2A | |
| SCHEMBL1196771 | 0.75 | F11 (0.49) | F11KLKB1 | |
| SCHEMBL1196922 | 0.75 | F11 (0.47) | F11KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007070826-A1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-21 | — | — | WO | disclosed |