Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 15/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8245759 | 0.77 | CYP11B2 (0.71) | CYP11B2CYP11B1CYP19A1KCNH2 | |
| SCHEMBL7767391 | 0.73 | CYP11B2 (0.47) | CYP11B2CYP11B1CYP19A1CYP17A1HRH1 | |
| SCHEMBL22502181 | 0.69 | TSHR (0.49) | — | |
| SCHEMBL7056177 | 0.65 | GAA (0.59) | — | |
| SCHEMBL3786692 | 0.64 | GLA (0.53) | — | |
| SCHEMBL9117478 | 0.64 | GAA (0.53) | — | |
| SCHEMBL11416116 | 0.64 | CYP1A2 (0.61) | KCNH2 | |
| SCHEMBL7771681 | 0.63 | CYP19A1 (0.62) | CYP11B2CYP11B1CYP19A1KCNH2 | |
| SCHEMBL11687770 | 0.62 | KDM4E (0.51) | — | |
| SCHEMBL11701198 | 0.62 | KDM4E (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007024945-A1 | CONDENSED IMIDAZOLO DERIVATIVES FOR THE INHIBITION OF ALDOSTERONE SYNTHASE AND AROMATASE | NOVARTIS AG (CH) | 2007-03-01 | — | — | WO | disclosed |