Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.41 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.41 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.41 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380274 | 0.85 | PIK3CA (0.53) | PIK3CAPIK3CBPIK3CGAKT3JAK2 | |
| SCHEMBL4583186 | 0.84 | PIK3CA (0.44) | L3MBTL1LMNAPIK3CAPIK3CBPIK3CG | |
| SCHEMBL8230866 | 0.82 | PIK3CA (0.47) | PIK3CAPIK3CBPIK3CGAKT3JAK2 | |
| SCHEMBL4385243 | 0.81 | JAK2 (0.63) | PIK3CAPIK3CBPIK3CGAKT3JAK2 | |
| SCHEMBL13588448 | 0.80 | PIK3CA (0.52) | PIK3CAPIK3CBPIK3CGAKT3JAK2 | |
| SCHEMBL4387875 | 0.80 | PIK3CA (0.46) | ALDH1A1PIK3CAPIK3CBPIK3CGAKT3 | |
| SCHEMBL13588449 | 0.77 | PIK3CA (0.47) | PIK3CAPIK3CBPIK3CGAKT3JAK2 | |
| SCHEMBL5093415 | 0.72 | PIK3CA (0.55) | ALDH1A1PIK3CAPIK3CBPIK3CGCCNT1 | |
| SCHEMBL5000363 | 0.70 | AKT3 (0.78) | AKT3 | |
| SCHEMBL5006003 | 0.67 | AKT3 (0.79) | AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |