Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.42 |
| ▸ | CCR4 | P51679 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | XBP1 | P17861 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8239154 | 0.80 | L3MBTL1 (0.46) | PIK3CAPIK3CBPIK3CGMAPTHTT | |
| SCHEMBL4380274 | 0.79 | PIK3CA (0.53) | PIK3CAPIK3CBPIK3CGCCR4MAPT | |
| SCHEMBL4583186 | 0.79 | PIK3CA (0.44) | PIK3CAPIK3CBPIK3CGMAPTHTT | |
| SCHEMBL4385243 | 0.75 | JAK2 (0.63) | PIK3CAPIK3CBPIK3CGMAPTNPC1 | |
| SCHEMBL13588448 | 0.75 | PIK3CA (0.52) | PIK3CAPIK3CBPIK3CGCCR4MAPT | |
| SCHEMBL5093415 | 0.73 | PIK3CA (0.55) | PIK3CAPIK3CBPIK3CGMAPTNPC1 | |
| SCHEMBL8230866 | 0.73 | PIK3CA (0.47) | PIK3CAPIK3CBPIK3CGCCR4MAPT | |
| SCHEMBL13588449 | 0.72 | PIK3CA (0.47) | PIK3CAPIK3CBPIK3CGCCR4MAPT | |
| SCHEMBL4564816 | 0.68 | PIK3CG (0.54) | PIK3CAPIK3CBPIK3CGCCR4MAPT | |
| SCHEMBL5000363 | 0.66 | AKT3 (0.78) | AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440663-B2 | 4-aryl-2-amino-pyrimidines or 4-aryl-2-aminoalkyl-pyrimidines as JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2013-05-14 | — | — | US | disclosed |
| US-20090298830-A1 | 4-Aryl-2-Amino-Pyrimidnes or 4-Aryl-2-Aminoalkyl-Pyrimidines as Jak-2 Modulators and Methods of Use | EXELIXIS, INC. (US) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298830-A1 | 4-Aryl-2-Amino-Pyrimidnes or 4-Aryl-2-Aminoalkyl-Pyrimidines as Jak-2 Modulators and Methods of Use | JAK2, JAK1, JAK3 | PIK3CA 854/4885PIK3CB 1083/4885PIK3CG 847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.