SCHEMBL8239164

SCHEMBL8239164

O=C(O)CNC(=O)c1sc2ncccc2c1-c1ccc(F)cc1

nearest known ligand 0.78

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 1/20 0.44
EGLN2 Q96KS0 1/20 0.42
FTO Q9C0B1 1/20 0.42
KDM4E B2RXH2 1/20 0.42
ALDH1A1 P00352 1/20 0.42
TP53 P04637 2/20 0.42
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13605661 0.88 TP53 (0.45) KDM4ETP53MAPT
SCHEMBL4515159 0.87 KMT2A (0.51) TP53MAPT
SCHEMBL4533208 0.83 KDM4E (0.49) KDM4EALDH1A1
SCHEMBL13605653 0.83 MAPT (0.58) ALDH1A1TP53MAPT
SCHEMBL8241900 0.82 ADORA2A (0.56) KDM4EALDH1A1MAPT
Hydrochloric Acid SCHEMBL4520231 0.82 KDM4E (0.48) KDM4EALDH1A1
SCHEMBL8239980 0.79 IKBKB (0.43) KDM4EALDH1A1
SCHEMBL27724629 0.79 TP53 (0.55) KDM4ETP53MAPT
SCHEMBL4518456 0.78 MAPT (0.43) KDM4EALDH1A1MAPT
SCHEMBL4524608 0.77 KAT2B (0.42) KDM4EALDH1A1TP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007072090-A1 THIENOPYRIDINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS RICHTER GEDEON NYRT. (HU) 2007-06-28 WO disclosed