Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.71 |
| ▸ | NAMPT | P43490 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | CASP6 | P55212 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | FASN | P49327 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636273 | 0.82 | NAMPT (0.61) | ALDH1A1NAMPTKDM4ETSHRHSD17B10 | |
| SCHEMBL14963886 | 0.82 | HPGD (0.71) | ALDH1A1NAMPTHTTPOLBMEN1 | |
| SCHEMBL189163 | 0.79 | ALDH1A1 (0.69) | ALDH1A1NAMPTKDM4ETSHRHSD17B10 | |
| SCHEMBL1663638 | 0.78 | TDP1 (0.73) | ALDH1A1NAMPTKDM4EHSD17B10HTT | |
| SCHEMBL3216413 | 0.76 | TDP1 (0.66) | ALDH1A1NAMPTKDM4EHSD17B10HTT | |
| SCHEMBL12156680 | 0.76 | ALDH1A1 (0.52) | ALDH1A1KDM4ETSHRHSD17B10HTT | |
| SCHEMBL3706326 | 0.76 | NAMPT (1.00) | NAMPT | |
| Hydrochloric Acid SCHEMBL3205122 | 0.75 | TDP1 (0.64) | ALDH1A1NAMPTKDM4EHSD17B10HTT | |
| SCHEMBL3209251 | 0.74 | KMT2A (0.59) | ALDH1A1NAMPTKDM4ETSHRHSD17B10 | |
| SCHEMBL28312550 | 0.74 | RECQL (0.63) | ALDH1A1KDM4ETSHRHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |