Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | RORA | P35398 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | RORB | Q92753 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6211629 | 0.91 | HSD17B10 (0.72) | HSD17B10MAPK1NR1I2CYP2C9ALDH1A1 | |
| SCHEMBL6732624 | 0.90 | HSD17B10 (0.71) | HSD17B10MAPK1NR1I2CYP2C9ALDH1A1 | |
| SCHEMBL6736757 | 0.89 | HSD17B10 (0.70) | HSD17B10MAPK1NR1I2CYP2C9ALDH1A1 | |
| SCHEMBL6739989 | 0.89 | HSD17B10 (0.74) | HSD17B10MAPK1NR1I2CYP2C9ALDH1A1 | |
| SCHEMBL6235919 | 0.88 | HSD17B10 (0.68) | HSD17B10MAPK1NR1I2CYP2C9ALDH1A1 | |
| SCHEMBL6235728 | 0.88 | HSD17B10 (0.68) | HSD17B10MAPK1NR1I2CYP2C9ALDH1A1 | |
| SCHEMBL6267293 | 0.88 | HSD17B10 (0.68) | HSD17B10MAPK1NR1I2CYP2C9ALDH1A1 | |
| SCHEMBL6235373 | 0.88 | HSD17B10 (0.74) | HSD17B10MAPK1NR1I2CYP2C9ALDH1A1 | |
| SCHEMBL6235081 | 0.87 | HSD17B10 (0.67) | HSD17B10MAPK1NR1I2CYP2C9ALDH1A1 | |
| SCHEMBL6209102 | 0.87 | MAPK1 (0.65) | HSD17B10MAPK1NR1I2CYP2C9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070274951-A1 | Combinations comprising HCV protease inhibitor(s) and HCV polymerase inhibitor(s), and methods of treatment related thereto | SCHERING CORPORATION | 2007-11-29 | — | — | US | disclosed |
| US-20070274951-A1 | Combinations comprising HCV protease inhibitor(s) and HCV polymerase inhibitor(s), and methods of treatment related thereto | SCHERING CORPORATION | 2007-11-29 | — | — | US | disclosed |
| WO-2007092616-A2 | COMBINATIONS COMPRISING HCV PROTEASE INHIBITOR(S) AND HCV POLYMERASE INHIBITOR(S), AND METHODS OF TREATMENT RELATED THERETO | SCHERING CORPORATION (US) | 2007-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070274951-A1 | Combinations comprising HCV protease inhibitor(s) and HCV polymerase inhibitor(s), and methods of treatment related thereto | PREP, CTRL, SERPINB1 | HSD17B10 1967/4885MAPK1 3574/4885NR1I2 2880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.