Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPFFR1 | Q9GZQ6 | 6/20 | 0.44 |
| ▸ | NPFFR2 | Q9Y5X5 | 6/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1036462 | 0.87 | NPFFR1 (0.52) | KMT2ANPFFR1NPFFR2SLC6A9CYP2D6 | |
| SCHEMBL7315847 | 0.81 | NPFFR1 (0.56) | NPFFR1NPFFR2CYP2D6ALDH1A1CNR1 | |
| SCHEMBL4161335 | 0.76 | KDM4E (0.48) | MEN1KMT2AOPRM1OPRK1KDM4E | |
| SCHEMBL28249793 | 0.76 | NPFFR1 (0.53) | KMT2ANPFFR1NPFFR2CYP2D6CYP3A4 | |
| SCHEMBL1031172 | 0.75 | NPFFR1 (0.53) | KMT2ANPFFR1NPFFR2CYP2D6CYP3A4 | |
| SCHEMBL3408119 | 0.75 | NPFFR1 (0.52) | NPFFR1NPFFR2OPRK1KDM4ECYP2D6 | |
| SCHEMBL19331129 | 0.74 | POLB (0.57) | SLC6A9KDM4ECYP2D6CYP3A4TSHR | |
| SCHEMBL23120819 | 0.74 | NPFFR1 (0.53) | KMT2ANPFFR1NPFFR2CYP2D6CYP3A4 | |
| SCHEMBL22961966 | 0.74 | NPFFR1 (0.53) | KMT2ANPFFR1NPFFR2CYP2D6CYP3A4 | |
| SCHEMBL4155932 | 0.74 | KDM4E (0.63) | MEN1KMT2AOPRM1OPRK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069287-A1 | SUBSTITUTED AZACYCLOALKANES USEFUL FOR TREATING CNS CONDITIONS | PFIZER INC | 2009-03-12 | — | — | US | disclosed |
| US-20090069287-A1 | SUBSTITUTED AZACYCLOALKANES USEFUL FOR TREATING CNS CONDITIONS | PFIZER INC | 2009-03-12 | — | — | US | disclosed |
| WO-2007060526-A1 | SUBSTITUTED AZACYCLOALKANES USEFUL FOR TREATING CNS CONDITIONS | PFIZER PRODUCTS INC. (US) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069287-A1 | SUBSTITUTED AZACYCLOALKANES USEFUL FOR TREATING CNS CONDITIONS | BACE2, BACE1, PMP22 | MEN1 1661/4885KMT2A 2570/4885NPFFR1 2554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.