Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 0.76 |
| ▸ | FLT3 | P36888 | 20/20 | 0.76 |
| ▸ | JAK2 | O60674 | 19/20 | 0.76 |
| ▸ | CCNA2 | P20248 | 19/20 | 0.76 |
| ▸ | CCNA1 | P78396 | 19/20 | 0.76 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.71 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | CCNK | O75909 | 1/20 | 0.51 |
| ▸ | STK10 | O94804 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | PRKCB | P05771 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | FER | P16591 | 1/20 | 0.51 |
| ▸ | PRKCA | P17252 | 1/20 | 0.51 |
| ▸ | ERCC2 | P18074 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL824012 | 0.86 | JAK2 (1.00) | CDK2FLT3JAK2CCNA2CCNA1 | |
| SCHEMBL824026 | 0.86 | JAK2 (0.78) | CDK2FLT3JAK2CCNA2CCNA1 | |
| SCHEMBL823862 | 0.84 | JAK2 (0.76) | CDK2FLT3JAK2CCNA2CCNA1 | |
| SCHEMBL823931 | 0.83 | CDK2 (1.00) | CDK2FLT3JAK2CCNA2CCNA1 | |
| SCHEMBL823992 | 0.83 | JAK2 (0.78) | CDK2FLT3JAK2CCNA2CCNA1 | |
| SCHEMBL824009 | 0.80 | JAK2 (0.63) | CDK2FLT3JAK2CCNA2CCNA1 | |
| SCHEMBL14531120 | 0.75 | FLT3 (0.84) | CDK2FLT3JAK2CCNA2CCNA1 | |
| SCHEMBL823991 | 0.74 | CDK2 (0.81) | CDK2FLT3JAK2CCNA2CCNA1 | |
| SCHEMBL824029 | 0.73 | JAK2 (0.66) | CDK2FLT3JAK2CCNA2CCNA1 | |
| SCHEMBL824008 | 0.72 | JAK2 (1.00) | CDK2FLT3JAK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133214-B2 | Heteroalkyl linked pyrimidine derivatives | S*BIO PTE LTD (SG) | 2015-09-15 | — | — | US | disclosed |
| US-9133214-B2 | Heteroalkyl linked pyrimidine derivatives | S*BIO PTE LTD (SG) | 2015-09-15 | — | — | US | disclosed |
| US-20120142680-A1 | HETEROALKYL LINKED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD. (SG) | 2012-06-07 | — | — | US | disclosed |
| US-20120142680-A1 | HETEROALKYL LINKED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD. (SG) | 2012-06-07 | — | — | US | disclosed |
| US-8143255-B2 | Heteroalkyl linked pyrimidine derivatives | S*BIO PTE LTD. (SG) | 2012-03-27 | — | — | US | disclosed |
| US-8143255-B2 | Heteroalkyl linked pyrimidine derivatives | S*BIO PTE LTD. (SG) | 2012-03-27 | — | — | US | disclosed |
| US-20090258886-A1 | HETEROALKYL LINKED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD. (SG) | 2009-10-15 | — | — | US | disclosed |
| US-20090258886-A1 | HETEROALKYL LINKED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD. (SG) | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258886-A1 | HETEROALKYL LINKED PYRIMIDINE DERIVATIVES | TK1, TK2, DPYD | CDK2 13/4885FLT3 424/4885JAK2 692/4885 |
| US-20120142680-A1 | HETEROALKYL LINKED PYRIMIDINE DERIVATIVES | TK1, TK2, DPYD | CDK2 13/4885FLT3 424/4885JAK2 692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.