Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 16/20 | 0.65 |
| ▸ | AKT2 | P31751 | 1/20 | 0.63 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8240376 | 0.86 | AKT1 (0.65) | AKT1AKT2AKT3 | |
| SCHEMBL8239758 | 0.85 | AKT1 (0.64) | AKT1AKT2AKT3 | |
| SCHEMBL8240352 | 0.83 | AKT1 (0.66) | AKT1AKT2AKT3 | |
| SCHEMBL4583102 | 0.82 | AKT1 (0.72) | AKT1AKT2AKT3 | |
| SCHEMBL4583238 | 0.79 | AKT1 (1.00) | AKT1AKT2AKT3 | |
| SCHEMBL8234030 | 0.79 | AKT1 (0.68) | AKT1AKT2AKT3 | |
| SCHEMBL29644967 | 0.78 | AKT1 (1.00) | AKT1AKT2AKT3 | |
| SCHEMBL21067542 | 0.78 | AKT1 (1.00) | AKT1AKT2AKT3 | |
| SCHEMBL4585624 | 0.78 | AKT1 (1.00) | AKT1AKT2AKT3 | |
| SCHEMBL4120383 | 0.78 | IKBKB (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |