Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 19/20 | 0.72 |
| ▸ | AKT2 | P31751 | 2/20 | 0.65 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.65 |
| ▸ | DHPS | P49366 | 1/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | PRKCG | P05129 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | MARK3 | P27448 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583154 | 0.87 | AKT1 (0.72) | AKT1AKT2AKT3DHPSMAPK13 | |
| SCHEMBL4584364 | 0.85 | AKT1 (0.66) | AKT1AKT2AKT3PIM1MAPKAPK2 | |
| SCHEMBL4583238 | 0.84 | AKT1 (1.00) | AKT1AKT2AKT3 | |
| SCHEMBL4585624 | 0.83 | AKT1 (1.00) | AKT1AKT2AKT3 | |
| SCHEMBL29644967 | 0.83 | AKT1 (1.00) | AKT1AKT2AKT3 | |
| SCHEMBL21067542 | 0.83 | AKT1 (1.00) | AKT1AKT2AKT3 | |
| SCHEMBL8239803 | 0.82 | AKT1 (0.65) | AKT1AKT2AKT3 | |
| SCHEMBL4583517 | 0.79 | AKT1 (1.00) | AKT1AKT2AKT3 | |
| SCHEMBL4599906 | 0.79 | AKT1 (1.00) | AKT1AKT2AKT3 | |
| SCHEMBL4585423 | 0.79 | AKT1 (1.00) | AKT1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | claimed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |